How PYRUKYND® works
Imagine the first and only treatment to
target the cause of your PK deficiency
See how PYRUKYND is
thought to work in your body
Individual results may vary.
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Take a closer look at how
PYRUKYND is thought to work:
By activating the defective PK enzyme that causes the rapid breakdown of red blood cells (hemolysis), PYRUKYND may help your red blood cells (RBCs) live longer.
PYRUKYND starts by attaching and binding to the
defective PK enzyme
Once attached, PYRUKYND activates
the PK enzyme to help improve its
function, and increase energy, or ATP (as seen in
healthy people without PK deficiency)
Helps increase energy (ATP) to slow the process of RBC
breakdown (hemolysis) and helps them live longer
Important Safety Information
What is PYRUKYND?
PYRUKYND is a prescription medicine used to treat low red blood cell counts caused by the early breakdown of red blood cells (hemolytic anemia) in adults with pyruvate kinase (PK) deficiency.
It is not known if PYRUKYND is safe and effective in children.
Important Safety Information
PYRUKYND may cause serious side effects, including:
- Rapid breakdown of red blood cells (acute hemolysis) has happened after suddenly interrupting or stopping treatment with PYRUKYND. You should not suddenly stop taking PYRUKYND. If you have to stop your treatment with PYRUKYND, your healthcare provider should monitor you closely. Tell your healthcare provider right away if you develop any signs or symptoms of breakdown of red blood cells including yellowing of the skin or the whites of your eyes (jaundice), dark colored urine, dizziness, confusion, feeling tired, or shortness of breath
The most common side effects of PYRUKYND were decrease in reproductive hormone (estrone) in men, increased salt from uric acid (urate) blood test, back pain, decrease in reproductive hormone (estradiol) in men, and joint pain (arthralgia).
These are not all the possible side effects of PYRUKYND. Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Before taking PYRUKYND, tell your healthcare provider about all of your medical conditions, including if you:
- have liver problems
- are pregnant or plan to become pregnant. It is not known if PYRUKYND will harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment with PYRUKYND
- are breastfeeding or plan to breastfeed. It is not known if PYRUKYND passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with PYRUKYND
Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. PYRUKYND and certain other medicines may affect each other causing side effects. PYRUKYND may affect the way other medicines work, and other medicines may affect how PYRUKYND works. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.
Please see full Prescribing Information, including Patient Information.